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Polynucleotides vs Profhilo – which treatment is right for you?
The field of aesthetic medicine is constantly evolving, with new treatments that address the signs of ageing by harnessing natural processes that repair and regenerate the skin.
Polynucleotides and Profhilo are two prominent treatments for skin rejuvenation. Both offer very specific mechanisms and benefits, making them suitable for different skin concerns and desired outcomes.
Here, we explain the unique properties of polynucleotides and Profhilo, to help you understand their roles in skin care and which might be most beneficial for you.
Understanding polynucleotides
Polynucleotides are chains of molecules called nucleotides that form the structure of DNA.
When delivered into the skin via an injectable solution, polynucleotides stimulate dermal cells called fibroblasts to produce collagen fibres and encourage cell turnover.
This activity promotes the skin’s natural ability to repair damaged tissue, achieving overall rejuvenation to the skin.
The key benefits of polynucleotides treatment:
- Tissue repair – Polynucleotides repair damaged skin tissue, making this treatment highly effective for reducing acne scarring.
- Hydration – Polynucleotides are deeply hydrating. They improve overall skin texture.
- Anti-inflammatory – Polynucleotides have anti-inflammatory properties that can reduce redness and swelling, to aid skin healing.
- Elasticity – By stimulating collagen and elastin production, over time, polynucleotides improve skin elasticity and firmness.
Polynucleotides are highly versatile and can be used to treat skin issues such as aging, scarring, and general skin revitalisation.
Treatment approach and longevity
Because treatment with polynucleotides stimulates the skin’s ability to repair and regenerate itself, its results are not instantaneous but evolve over time.
We usually recommend 2 or 3 treatments, 2 weeks apart. The initial benefits of polynucleotides treatment are visible around 7-10 days following treatment and improve over several weeks. The results can last for up to 12 months.
Understanding Profhilo
Profhilo is an injectable treatment composed of high concentrations of hyaluronic acid.
Hyaluronic acid is a naturally occurring chemical which the body uses to retain water in the skin and support collagen and elastin.
Unlike dermal fillers, Profhilo does not just fill wrinkles but works by ‘bio-remodelling’ the skin. It spreads evenly across the skin, stimulating natural rejuvenating processes.
The key benefits of Profhilo:
- Hydration – Profhilo intensively hydrates the skin by attracting and retaining water, resulting in a plumper and more radiant complexion.
- Elasticity and firmness – Profhilo enhances skin firmness and elasticity by promoting the synthesis of collagen and elastin.
- Natural approach – Profhilo spreads seamlessly within the skin, ensuring a natural and even improvement in skin texture and tone.
- Immediate results – Profhilo treatment has minimal to no downtime and the hydrating benefits are often apparent immediately.
Profhilo is predominantly used to treat skin laxity and is particularly effective for areas such as the face, neck, décolletage, and hands.
Treatment approach and longevity
With Profhilo, the hydrating effects are often immediately noticeable. It continues to work in the skin for around a month following treatment.
A top-up Profhilo treatment is recommended every six months to maintain the benefits.
Polynucleotides vs Profhilo, at a glance
| Polynucleotides | Profhilo | |
| Composition | Derived from salmon DNA, focusing on cellular repair and regeneration | High concentrations of hyaluronic acid, focusing on hydration and skin bio-remodelling |
| Benefits | Tissue repair, anti-inflammatory effects, and enhanced skin elasticity | Intense hydration, improved skin firmness |
| Mechanism of action | Works at a cellular level to repair and regenerate skin tissue | Spreads across the skin to stimulate collagen and elastin production |
| Results onset | Over several weeks | Immediate |
| Results duration | Up to 12 months | Up to 6 months |
| Applications | Suitable for a variety of skin concerns, including scarring, aging, and general skin revitalisation | Primarily used for skin laxity and overall rejuvenation |
| Treatment areas | Face, neck, décolletage and hands | Face, neck, décolletage, chest, stomach, inner arms, hands and knees |
The most appropriate treatment for you
Both polynucleotides and Profhilo offer significant benefits for skin rejuvenation, but the best option for each individual patient will depend on their skin type and desired outcome.
Polynucleotides are ideal for patients looking for longer-lasting improvement in the overall texture and appearance of their skin through tissue repair.
Profhilo is a good option for patients seeking intense hydration and an immediate, rejuvenating effect.
At your free initial consultation, we will discuss your desired results and preferences, to ascertain the best approach for you.
To book your appointment, you can book online, call us or email info@meliorclinics.co.uk.
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