Polynucleotides are one of the most exciting developments in aesthetic medicine, offering powerful regenerative benefits without adding volume or altering facial structure. Whether you’re new to the treatment or considering it as part of your skincare journey, this guide answers the most common questions.
About polynucleotides
What are polynucleotides?
Polynucleotides are purified DNA molecules that stimulate the skin’s natural regeneration process. They work by encouraging fibroblast activity, boosting collagen and elastin production, and improving tissue hydration. Unlike dermal fillers, they do not add volume to the face. Instead, they restore and rejuvenate the skin from within, improving texture, tone, and elasticity over time.
These treatments are typically derived from salmon or trout DNA, which is highly biocompatible with human tissue once it has been extensively purified to remove any proteins or allergens.
According to a clinical review published in the Journal of Aesthetic Nursing, polynucleotides have demonstrated significant improvements in skin hydration, elasticity and overall dermal health, primarily by stimulating cellular repair, collagen synthesis and anti-inflammatory activity.
Are polynucleotides a filler?
No. Although injected into the skin like dermal fillers, polynucleotides do not add volume. Instead, they act as a skin-regenerating treatment that improves tone, texture and elasticity by stimulating your body’s natural healing mechanisms. They are best considered a regenerative skin booster.
Is Lumi Eyes a polynucleotide?
Yes, Lumi Eyes is a polynucleotide-based injectable designed specifically for the under-eye area. It targets dark circles, fine lines and dehydration to promote cellular repair and tissue regeneration in this delicate part of the face without adding bulk or puffiness.
Can you have polynucleotides and botox together?
Yes. Polynucleotides and botox work in different ways and can complement each other effectively. Botox targets dynamic lines by relaxing muscle movement, while polynucleotides improve skin quality and resilience.
Can you have Profhilo and polynucleotides together?
Yes, and many patients see enhanced results by alternating between the two. Profhilo provides deep hydration using hyaluronic acid, while polynucleotides regenerate and repair the skin’s structure. Your practitioner can recommend a schedule that maximises the benefits of both treatments.
Do polynucleotide injections hurt?
Treatment is usually well tolerated, especially with the use of a topical numbing cream. You may feel a mild stinging or pressure during the injections, but the procedure is generally quick and comfortable. Any discomfort typically resolves shortly after the treatment.
Are polynucleotides made from salmon sperm?
Yes, many polynucleotide products use DNA extracted from salmon or trout sperm. This source is chosen for its biocompatibility with human tissue. The DNA is then highly purified, ensuring it is safe, sterile, and free from proteins that could trigger allergic reactions.
How much do polynucleotides cost?
Prices vary depending on the treatment area and the number of sessions required. Most patients need a course of two or three treatments for best results, followed by maintenance appointments. For current pricing and package options, please visit our price list.
What are the benefits of polynucleotides?
Polynucleotides help restore skin health and quality from the inside out. They can:
- Improve crepey skin by boosting elasticity and hydration. Read more in our blog post on treating crepey skin
- Reduce the appearance of fine lines and wrinkles. Learn more on our lines and wrinkles condition page
- Brighten and smooth the under-eye area. Learn more in our blog on treatments for bags under the eyes
- Enhance overall skin texture, tone, and resilience
Are polynucleotides vegetarian or vegan?
Polynucleotide products are not suitable for vegetarians or vegans. They are typically derived from purified DNA extracted from salmon or trout. Although highly refined and free of proteins, the source material is animal-based.
Are polynucleotides kosher?
Polynucleotide products are not certified kosher. They are derived from fish DNA and do not undergo kosher supervision or certification.
What it’s like to have polynucleotide treatment
What is polynucleotide treatment like?
Polynucleotides are administered as injectable treatments. A fine needle or cannula is used to deliver the product into the superficial to mid-dermal layers of the skin, depending on the treatment area and indication.
The injections are usually placed in a series of small points across the target area, allowing for even distribution and optimal regeneration.
How long do polynucleotides take to work?
You may start to see early results within seven to ten days after your first treatment. Following the recommended course of treatment, results last for six to twelve months.
How long do polynucleotides last?
Results from polynucleotide treatments can last between six and twelve months. Longevity depends on factors such as age, skin condition, lifestyle, and the specific product used. Maintenance sessions are recommended to sustain long-term benefits.
How many sessions of polynucleotides do you need?
Two or three treatments, spaced two weeks apart, are recommended to achieve optimal results. This course allows the polynucleotides to stimulate collagen production and support tissue regeneration effectively. Your practitioner will assess your skin and advise on the most suitable number of sessions based on your individual concerns and goals.
Are polynucleotides permanent?
Polynucleotide treatments are not permanent. They work by stimulating your body’s own collagen and tissue repair processes over time. While results are long-lasting, typically six to twelve months, maintenance treatments are required to preserve the effects.
What are polynucleotide used for?
What areas can be treated with polynucleotides?
Common treatment areas include:
- Under-eye region.
- Face and neck.
- Décolletage.
Do polynucleotides work under eyes?
Yes. Polynucleotides are particularly effective in the under-eye area, where they improve skin quality, reduce dark circles, and target fine lines without the risk of puffiness. This makes them a popular alternative to traditional under-eye fillers.
Can polynucleotides help with scarring?
Yes, polynucleotides have shown promise in supporting the treatment of certain types of scarring, particularly acne scarring. According to PMFA Journal, by encouraging collagen synthesis and cell regeneration, polynucleotides can help soften the appearance of scar tissue and improve skin quality over time.
For deeper or more established scars, a combined approach may be more effective. You can read more about our scar treatments here or explore our blog post on how to treat scars.
Safe use of polynucleotides
Are polynucleotides safe?
Yes. When performed by a qualified medical professional, polynucleotide treatments have an excellent safety profile. Polynucleotides have been used for years in both aesthetic and medical settings to support skin regeneration and tissue repair. Adverse effects are rare, with most patients only experiencing mild and temporary side effects such as redness, swelling, or minor bruising at the injection site.
Source: https://www.healthandaesthetics.co.uk/advice/are-polynucleotides-safe/
The Joint Council for Cosmetic Practitioners (JCCP) strongly advises the public to seek treatment only from practitioners who are trained, insured, and listed on an accredited register such as Save Face or the CQC. This ensures that injectables like polynucleotides are administered safely, ethically, and in line with UK standards.
Can polynucleotides cause a vascular occlusion?
The risk is extremely low. Polynucleotides are not volumising and are usually injected into superficial layers of the skin, which reduces the likelihood of vascular occlusion. Nevertheless, all injectable treatments carry some risk, so it is essential to choose a qualified medical practitioner.
Can polynucleotides create a vascular response?
Some patients may experience mild redness or a feeling of warmth around the treated area, which is part of a normal localised vascular response. This is temporary and typically subsides within a few hours or days.
Can you drink alcohol after polynucleotides?
It is advisable to avoid alcohol for at least 24 hours after your treatment. Alcohol can increase the likelihood of bruising and may interfere with the body’s healing response. Staying hydrated and avoiding strenuous activity will support the best outcome.
Can you have polynucleotides when pregnant?
No. Like most injectable treatments, polynucleotides are not recommended during pregnancy or while breastfeeding due to a lack of safety data.
How long does swelling last after polynucleotides?
Swelling is typically mild and resolves within 24 to 72 hours. When treating delicate areas such as under the eyes, some puffiness may persist slightly longer but is usually short-lived. Following aftercare advice will help minimise any side effects.
Will I bruise after polynucleotides treatment?
Some bruising is possible, especially in more delicate areas such as under the eyes. This is a normal and temporary side effect of injectable treatments and usually resolves within a few days. To minimise the risk, avoid alcohol, aspirin, and vigorous exercise for 24 hours before and after treatment. Your practitioner will also give tailored aftercare advice to support a smooth recovery.
Who can carry out polynucleotides treatment?
Polynucleotide treatments should only be performed by trained and medically qualified professionals. At Melior Clinics, all injectable treatments are carried out by experienced and qualified practitioners and our clinics are Save Face and CQC registered.
How old do you have to be to have polynucleotides?
Strictly speaking, there is no minimum age for polynucleotides treatment. However, like other skin boosters, they are designed for people age 18 and over, and reputable clinics would not offer this or any aesthetic treatment to under 18s without a compelling medical reason
Can you be allergic to polynucleotides?
Allergic reactions to polynucleotides are extremely rare. The DNA used is highly purified and free from immunogenic proteins. However, as with any injectable treatment, there is a small risk of sensitivity or reaction. During your consultation, your practitioner will review your medical history to ensure the treatment is appropriate and safe for you.
Polynucleotides treatment at Melior Clinics
Polynucleotides offer a natural and regenerative approach to aesthetic treatment, helping to restore healthy, glowing skin without changing your facial structure. Whether used alone or in combination with other treatments, they provide subtle yet transformative results for those seeking rejuvenation.
For personalised advice and treatment planning, we always recommend booking a consultation with one of our expert medical practitioners at Melior Clinics. Our team will guide you through the process and help you achieve beautifully refreshed, natural-looking skin. To book your appointment, you can book online, call us on 0330 024 1300 or email info@meliorclinics.co.uk