
Nucleofill polynucleotides
Polynucleotides skin rejuvenation, or ‘PN treatment’, is becoming a highly popular aesthetic treatment for its ability to rejuvenate, regenerate and refresh the skin.
As we age, several factors can influence the texture and vitality of our skin. These include sun exposure, lifestyle, and importantly, the decrease in collagen and elastin production, which can lead to skin laxity and the formation of fine lines, wrinkles, and pigmentation issues.
PN treatment acts on the fibroblasts within your skin, to promote the production of new collagen fibres.
This stimulates the skin’s regenerative processes to enable skin healing and rejuvenation. Polynucleotide treatment is also deeply hydrating and has anti-inflammatory properties.
Overview of polynucleotides treatment
Benefits of polynucleotides
PN treatment has the following benefits:
- Skin regeneration at a cellular level, resulting in overall revitalisation
- Deep hydration to improve skin texture
- Visibly lifted, firmer skin
- Reduction in fine lines and wrinkles
- Reduction in the appearance of scarring and pigmentation
- Anti-inflammatory properties to aid skin healing
Nucleofill polynucleotides prices
All appointments include a free, no-obligation consultation. Call our team on 0330 024 1300 for more information.
Find out more or book your consultation

By sending this form you agree to our privacy policy. This form is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Reviews for our Nucleofill polynucleotides treatment
What is polynucleotides treatment like?

Initial consultation
All patients have a free initial consultation, so that our experts can fully assess your skin and ensure that both you, and we, are happy that the approach is right for you. If so, the treatment can be administered straight away.
Your treatment
The treatment itself will take around 30 to 45 minutes, depending on the area(s) to be treated.
A topical numbing cream will be applied before the treatment to ensure you are comfortable throughout.
Our polynucleotides experts
Polynucleotides – your questions answered
What are polynucleotides?
Polynucleotides are high molecular weight DNA and RNA chain structures.
Polynucleotides skin rejuvenation treatment involves these structures being administered to the skin via an injectable skin booster solution.
How does polynucleotides skin rejuvenation work?
Polynucleotides work by stimulating your skin’s natural repair processes.
They boost collagen and elastin production, improve hydration, and reduce inflammation. Over time, this helps to restore skin quality, making it firmer, smoother, and more radiant.
What is the science behind polynucleotides?
PN treatment uses molecules called nucleotides, which are known in medical science as the building blocks of DNA and RNA.
Polynucleotides are essentially an injectable skin booster, which stimulate activity of dermal cells within the subcutaneous connective tissue, called fibroblasts. Fibroblasts are responsible for collagen production.
By stimulating fibroblasts to produce collagen, PN treatment promotes the skin’s natural healing processes to repair damaged tissue, deeply hydrate, and give overall rejuvenation to the skin.
In addition, polynucleotide injections bring anti-inflammatory properties that assist with skin healing.
Further reading:
What are the benefits of PN treatment?
The benefits of PN treatment include skin firmness, improved skin texture, deeply hydrated skin, reduced appearance of fine lines and wrinkles and reduced scarring and pigmentation.
By promoting collagen production, PN treatment achieves overall skin rejuvenation.
What areas can be treated with polynucleotides?
Polynucleotides under eyes, face and neck treatments are very popular, although any areas of the body can be treated.
How many treatments are recommended?
Your practitioner will discuss your treatment plan with you at your initial consultation, we usually recommend 2 or 3 treatments, 2 weeks apart, to achieve optimal results.
What can I expect following PN treatment?
Patients may experience some redness and swelling immediately following treatment, but this should subside within a few hours.
There is little to no downtime with PN treatment.
What does polynucleotides treatment cost?
Please see above for the prices of PN treatment.
How quickly will I see the benefits of PN treatment?
Patients start to see the benefits of PN treatment around 7 to 10 days following treatment.
Following the recommended course of treatment, results last for 6 to 12 months.
Can I have polynucleotides in combination with other treatments?
Yes, polynucleotides are an ideal partner for other aesthetic treatments. Polynucleotides are often recommended to prepare the skin for certain treatments, such as peels and dermal fillers, because it can help to prolong their effects. Your practitioner will recommend the best approach for your desired outcome.
























