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What is Profhilo?

We’re delighted to now be offering Profhilo to our patients.

This ground-breaking treatment not only hydrates your skin, but it can also counteract the signs of aging, particularly sagging skin.

In this article we investigate the science behind Profhilo and what makes it so great.

What’s in Profhilo?

Profhilo contains pure, high grade hyaluronic acid. In a 2ml syringe there is a total of 64mg of hyaluronic acid (which is 50% low molecular weight hyaluronic acid and 50% high molecular weight hyaluronic acid).

It doesn’t contain any synthetic additives, such as BDDE, and is the first product of its kind.


Hyaluronic acid is a naturally occurring polymer which the body uses to keep cells hydrated and well supported. Around 50% of the body’s hyaluronic acid is found in the skin.

As well as its job as ‘scaffolding’ for your skin’s cells, it also plays an important role in protecting your skin from sun damage.

Your levels of hyaluronic acid decrease with age, contributing to aging symptoms such as sagging skin.


Profhilo contains both high molecular weight hyaluronic acid (1100-1400Kda) and low molecular weight hyaluronic acid (80-100Kda).

High and low molecular weight hyaluronic acid each have different advantages for your skin. The high molecular weight hyaluronic acid adds volume to your skin, resulting in a lifting effect. While the low molecular weight hyaluronic acid provides hydration, particularly to the epidermis (the surface layer of the skin).

They also work together to increase type I and type III collagen in your fibroblasts and type IV and VII collagen in your keratinocytes. Elastin production is also boosted by the treatment.

The patented thermal technology used to produce Profhilo stabilises the combined high and low molecular weight hyaluronic acid without the need for synthetic chemicals, such as BDDE.

The fact that Profhilo is a stabilised blend of high and low molecular weight hyaluronic acid means that it takes longer to break down and, therefore, has more time to work before your body naturally metabolises it.


Profhilo is…

the first BDDE-free stabilised injectable hyaluronic acid based product for treating skin laxity.

Why is this important?

To give it its full title, BDDE is “1,4-butanediol diglycidyl ether”. This is a chemical which is cross-linked (or bonded) to hyaluronic acid in many dermal fillers to slow the rate at which the body breaks them down.

Because Profhilo doesn’t contain BDDE there is a lower risk of hypersensitive reactions to the treatment and there’s the reassurance that you’re not introducing synthetic chemicals into your body.


Because Profhilo is a stabilised product, it stays in the skin for about a month after treatment. This longevity enables it to gradually hydrate your skin and stimulate four different types of collagen and elastin; natural tissues which break down over time and cause many of the symptoms of ageing skin.

It improves the quality of your skin in both the dermis (the main, thick layer of skin) and epidermis (the thin layer of skin above it), to maximise the anti-aging benefits.


Profhilo is said to ‘bioremodel’ your skin. It doesn’t just give it a boost of hydration, it can actually lift your skin back up and give you an incredibly rejuvenating effect.

It achieves this through the stimulation of collagen and elastin, which are responsible for the elasticity and firmness of your skin.

Before Profilho treatment and eight weeks after
Before Profhilo treatment and eight weeks after


Take a look at our Profhilo treatment page for more information.

We offer free, no-obligation consultations to all our patients, so call us on 0330 024 1300 or complete our booking form to speak to one of our experts about how Profhilo could help you look and feel great.

Your Profhilo treatment can take place at our London Harley Street, Sevenoaks, Huntingdon or Peterborough clinics.